Spinal Interneurons: Plasticity after Spinal Cord Injury

The spinal cord is comprised of four types of neurons: motoneurons, pre-ganglionic neurons, ascending projection neurons and spinal interneurons. Interneurons are neurons that process information within local circuits, but have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), interneurons are capable of sprouting and rewiring entire neural circuits, and some restoration of disrupted neural communication (i.e. bypassing the injury). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine optimal, cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal, diseased and injured neural circuits, and highlight the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book compiling the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse translated to the bench. Comprehensive overview of techniques used to identify, characterize and classify spinal interneurons and their role in neural circuitsIn-depth discussion of therapeutic potential of spinal interneurons for SCI injury and/or diseaseFirst book to discuss spinal interneurons and translational research edited by established leaders in spinal cord injury research INDICE: Section 1: Spinal Interneurons - Motor and Sensory Neuronal Networks 1. Spinal Interneurons: coordination and modulation in the adult spinal cord 2. Identifying spinal interneurons - lessons from developmental biology and genetics 3. Spinal Interneurons & Motor Function 4. Spinal interneurons and Sensory Function 5. Lessons from computational models Section 2: Spinal Interneurons - A role in injury and disease 6. Spinal interneurons after spinal cord injury - adaptive vs maladaptive neuroplasticity 7. Spinal interneurons and Breathing 8. Spinal interneurons and Bladder function 9. Spinal interneurons and Pain 10. Spinal interneurons in pre-clinical models of ALS Section 3: Spinal Interneurons - A therapeutic target for plasticity, repair and recovery 11. Introduction: Therapeutic potential of spinal interneurons Electrical stimulation

• ISBN: 978-0-12-819260-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/11/2020
• Nº Volúmenes: 1
• Idioma: Inglés