Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. Presents a comprehensive resource for computational methods for the identification and quantification of non-coding RNAsProvides a guide to assist biologists and other researchers dealing with complex datasetsIntroduces basic computational methods and provides guidelines for their replication by researchersOffers a solution to researchers approaching large and complex sequencing datasets INDICE: SECTION I: Genetic and Epigenetic effect on cancer through noncoding RNA 1. miRNA and Cancer 2. miRNA biogenesis disruption and cancer 3. Genetic alteration of miRNA affecting cancer pathways 4. The epigenetic control of microRNA expression and cancer 5. Effects of miRNAs on epigenetic machinery 6. Histone modifiers of deregulated miRNAs in cancer 7. miRNA genes epigenetically regulated by DNA methylation in cancer 8. Circulating miRNA increasing the risk of cancer 9. lncRNA as cancer biomarker 10. Genetic variation of lncRNA in cancer 11. Implications of lncRNAs in cancer epigenetics 12. Charting DNA methylation of long non-coding RNA in cancer. 13. Competing endogenous RNA and cancer 14. miRNA-lncRNA-ceRNA network in cancer 15. Noncoding function of protein-coding genes: mRNA 3´ UTR as ceRNAs in cancer 16. Long noncoding RNAs and pseudogenes as ceRNA in cancer 17. Epigenetic programming mechanism guided by piRNAs in cancer. 18. Epigenetic loss of the PIWI/piRNA machinery in human tumorigenesis 19. tRNA and cancer 20. Dynamic reprogramming of tRNA modifications in cancer 21. Post-transcriptional modifications of tRNA linked to cancer 22. Circular RNA: a novel non-coding RNA in Cancer 23. Other ncRNA and cancer SECTION II: Cancer Epigenetic Mechanisms modulated by non-coding RNA 24. Assessing DNA methylation and demethylation of noncoding RNA in cancer 25. Noncoding RNAs act as chromatin scaffold of histone modification complexes in cancer 26. Heterochromatin modulation by noncoding RNA in cancer 27. Noncoding RNAs (ncRNAs) mediate the recruitment of PcG control of gene expression in cancer. SECTION III: Therapeutic implications of ncRNA in cancer 28. Non-coding RNA involved in Cancer Stem Cell Therapy 29. Therapeutic strategies based on targeting ncRNAs for selective silencing 30. Clinical relevance of non-coding RNAs in Cancer 31. Non-coding RNAs: Novel Targets in anticancer drug development SECTION IV: Bioinformatics' detection of ncRNA in cancer 32. Cancer ncRNA discovery via High Throughput Sequencing 33. Non-coding RNAs as a cause of cancer: evidence from GWAS and reverse genetics. 34. A comparative evaluation of emerging tools for cancer ncRNA retrieval 35. Databases: a comprehensive resource of noncoding RNAs
- ISBN: 978-0-12-814365-0
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 350
- Fecha Publicación: 01/10/2018
- Nº Volúmenes: 1
- Idioma: Inglés