Lead optimization for medicinal chemists: pharmacokinetic properties of functional groups and organic compounds
Zaragoza D”rwald, Florencio
150,20 €(IVA inc.)
INDICE: INTRODUCTIONTHE DRUG DISCOVERY PROCESSPharmacokinetics-structure relationshipLEAD OPTIMIZATIONWhat limits/reduces oral Bioavailability?What limits/reduces Plasma Half Life?How to improve BBB-Penetration?How to avoid CYP-Inhibition/Induction?How to avoid Interaction with the human Ether-a-go-go related Gene (HERG)?Recent Examples of PK-Optimization in AnimalsTHE PHARMACOKINETICPROPERTIES OF COMPOUND CLASSESFUNCTIONAL GROUPSPHARMACOPHORESINDEX
- ISBN: 978-3-527-33226-7
- Editorial: Wiley-VCH
- Encuadernacion: Cartoné
- Páginas: 622
- Fecha Publicación: 25/04/2012
- Nº Volúmenes: 1
- Idioma: Inglés