Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease. Discusses the role of Schnurri-2, which plays a critical role in cell growth, signal transduction and lymphocyte development, in the generation of memory CD4 T cells Discusses the role of cytokines, novel costimulatory molecules and other signals coming from the microenvironment in the generation and maintenance of memory T cells Generation and maintenance of memory CD8 T cells during acute or chronic viral infection INDICE: Memory Th1/Th2 Cell Generation Controlled by Schnurri?2.- Transcriptional Regulat ion during CD8 T?Cell Imune Responses.- The Role of Interleukin?2 in Memory CD8 Cell Differentiation.- The Role of Inflamation in the Generation and Maintenance of Memory T Cells.- The Role of OX40 (CD134) in T?Cell Memory Generation.- The Role of Precursor Frequency in the Differentiat ion of Memory T Cells: Memory by Numbers.- CD8 T?Cell Memory Differentiat ion during Acute and Chronic Viral Infections.- Longevity of T?Cell Memory following AcuteViral Infection.- Principles of Memory CD8 T?Cells Generation in Relation to Protective Imunity.- Memory T cells in Rhesus Macaques.- Memory T?Cell Subsetsin Pa rasitic Infections.- Antigen Specific Memory T Cells and Their PutativeNeed for the Generation of Sustained Anti?Tumor Responses.- Memory T?Cell Responses and Survival in Human Cancer: Remember to Stay Alive.- Analysis of vacine?induced T cells in humans with cancer.- Memory T?Cell Homeosta sis and Senescence during Aging
- ISBN: 978-1-4419-6450-2
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 198
- Fecha Publicación: 27/08/2010
- Nº Volúmenes: 1
- Idioma: Inglés