Cancer cells are continuously interacting with the immune system of the host.These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating theprogression of the disease. Traditionally, the interplay between cancer cellsand host immunity has been studied systemically, with no particular attentionto the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. Novel topic in bio-medical research INDICE: Foreword - Tumor Microenvironment under the Magnifying Glass: A New Challenge to Cancer Immunologists. 1: Immune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor Progression. 2: Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by TumorCells. 3: Local Tumor Growth and Spontaneous Systemic T cell Responses in Cancer Patients: a Parodox and Puzzle. 4: Insights into mechanisms of immune resistance in the tumor microenvironment through molecular profiling. 5: Tumor Antigens as Modulators of the Tumor Microenvironment. 6: Tumor Cell Resistance toApoptosis by Infiltrating Cytotoxic Lymphocytes. 7: The Tumor Microenvironment as a Model for Tissue-Specific Rejection. 8: Functional Cytotoxicity of T Cells at the Tumor Environment. 9: Natural Killer Cells at the Tumors Microenvironment. 10: Contribution of the Microenvironment to the Pathogenesis of EBV-positive Hodgkin and NK/T-cell Lymphomas.
- ISBN: 978-1-4020-6749-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 335
- Fecha Publicación: 01/01/2008
- Nº Volúmenes: 1
- Idioma: Inglés