Neuropsychiatric Disorders and Epigenetics

Neurobehavioral Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neurobehavioral disorders. The volume is organized into 22 chapters representing individual neurological disorders, from Addiction to Stress. The epigenetic aspects of each disorder are addressed by at least two scientists with expertise in that research area. Particular emphasis is placed by each contributing author on potential epigenetic interventions. In an effort to cover a broad range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA, author contributions were selected accordingly. In addition the effects of environmental stimuli on epigenetic states is addressed in some chapters based on relevance to disease induction. Recent discoveries in epigenetic research enabled by advances in genomic technologies, have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders. Clearly neurobehavioral disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with high costs to society. Thus, these collected works will define epigenetics as a key player in neurobehavioral disorders, highlight the full spectrum of epigenetic mechanisms underlying such disorders and introduce the vast range of epigenetic therapies under development. Relates the effects of environmental stimuli on epigenetic states to neurological disease inductionAnalysis of the epigenetic basis for common neuropsychiatric disorders and how it guides treatment, providing insight and perspective to both clinicians and basic scientistsExtensive use of diagrams, illustrations and tables, and graphical abstracts for each subsection permits rapid review INDICE: Preface Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects 1. Introduction to Neuropsychiatric Disorders and Epigenetics Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson 2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders Anke Hoffmann and Dietmar Spengler 3. Epigenetic Biomarkers in Neuropsychiatric Disorders Chin-Chuen Lin, Tiao-Lai Huang Section II: Epigenetics of Neuropsychiatric Disorders 4. Epigenetics and Cognitive Disorders -Translational Aspects Fabio Coppedè 5. Epigenetics in Pervasive Developmental Disorders - Translational Aspects Takeo Kubota 6. Epigenetic causes of intellectual disability - the fragile X syndrome paradigm Elisabetta Tabolacci, Giovanni Neri 7. Epigenetics of Attention-Deficit Hyperactivity Disorder Nader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer 8. The epigenetics of brain aging and psychiatric disorders Huan Gong, Xiangru Xu 9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products Alain D. Dekker, Peter P. De Deyn and Marianne G. Rots 10. Epigenetics and Multiple Sclerosis Lara Kular, Gonçalo Castelo-Branco and Maja Jagodic 11. Epigenetics and Migraine Siew Hua Gan and Munvar Miya Shaik 12. The role of epigenetics in the pathophysiology of epilepsy Sung Min Nam and Kyung-Ok Cho 13. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment Marco M. Hefti and Nadejda Tsankova 14. Epigenetics and Cerebrovascular Diseases Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer 15. Epigenetics and Eating Disorders Helge Frieling, Vanessa Buchholz 16. Epigenetics in Obesity Brian M. Shewchuk 17. Epigenetics and Drug Addiction-Translational Aspects Jian Feng 18. Epigenetics and Alcohol Use Disorders Sneha Sagarkar and Amul Sakharkar Section III: Summary and Outlook 19. Summary and Outlook Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

• ISBN: 978-0-12-800226-1
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 01/10/2016
• Nº Volúmenes: 1
• Idioma: Inglés