Highlighting the critical importance of enzymes in pharmaceutical and biotechnology research, Enzyme Technologies presents thorough discussions on chemical biology of enzymes, redesigning binding and catalytic specificities of enzymes, and applications of enzymes to biotechnology research in the post–genomic era. This timely review presents researchers, students, and faculty with expert reviews of recent progress in comprehending molecular mechanisms of biosynthetic and biocatalytic processes as well as how to utilize that knowledge for practical applications. INDICE: A. Enzymes – essential workhorses in pharmaceutical research 1. Assay Technologies for Proteases Anuradha Roy,Gerald H. Lushington, James McGee, Rathnam Chaguturu 2. Discovery and development of isozyme–selective inhibitors involved in lipid metabolism Taichi Ohshiro, Hiroshi Tomoda 3. Covalent enzyme inhibitor in drug discovery and development Shujaath Mehdi 4. Preclinomics: Using Enzyme Assays and Rodent Models for Metabolic diseases Wu–Kuang Yeh, Richard G. Peterson B. Enzymes – indispensable tools for improving druggability 5. Enzymes and Targeted Activation of Prodrugs Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama , Longqin Hu 6. Evolution of an Orally Active Prodrug of Gemcitabine James R. McCarthy 7. Enzymatically Activated Phosphate and Phosphonate Prodrugs Ivan S. Krylov, Charles E. McKenna C. Enzymes – powerful weapons for correcting Nature’s errors 8. Treatment options for mucopolysaccharidosis type II (Hunter’s symdrome) Michael Beck 9. Enzyme replacement therapy for Fabry disease Ley Nadine Lacbawan, Wei Zheng,Ozlem Goker–Alpan 10. Methods and principles of pancreatic function tests Henrike von
- ISBN: 978-0-470-28626-5
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 356
- Fecha Publicación: 20/12/2013
- Nº Volúmenes: 1
- Idioma: Inglés