Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts andadvanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics,followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention. Examines bothfundamental concepts and advanced technologies in pharmacogenomics. INDICE: From the contents The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery.- Applications of Microarrays and Biochips in Pharmacogenomics.- Confounding in GeneticAssociation Studies and Its Solutions.- Pharmacogenetics of Membrane Transporters: A Review of Current Approaches.- Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy.- Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease.- G Protein-coupled Receptors Disrupted in Human Genetic Disease.- G Protein-coupled Receptor Pharmacogenetics.- Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders.- Pharmacogenomics in Alzheimer’s Disease.- Pharmacogenetics of Asthma.- >From SNPs to Functional Studies in Cardiovascular Pharmacogenomics.- Pharmacogenomics in Gastrointestinal Disorders.- Pharmacogenomics in Rheumatoid Arthritis.- Cancer Pharmacogenetics.
- ISBN: 978-1-58829-887-4
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 550
- Fecha Publicación: 01/04/2008
- Nº Volúmenes: 1
- Idioma: Inglés