Hedgehog signaling activation in human cancer andits clinical implications

Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients aswell as the general public. Presents up-to-date information in this exciting research area. Summarizesmajor advances made on hedgehog signaling mechanisms, activation of the pathway in various human cancer types. Highlights current challenges in our effortsto translate the basic biology into clinic. Provides insightful views suitable for graduate, undergraduate, and medical students, basic and clinical scientists, cancer patients as well as the general public. INDICE: Overview of hedgehog signaling pathway. Regulation of Hh morphogene gradient. Smoothened Signaling through a G-protein Effector Network.- Kinases and phosphatases in hedgehog signaling. Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer.- Crosstalks between PKC and hedgehog signaling.- Activation of Hh signaling in human cancer.- Hedgehog signaling in pediatric brain tumors. Hedgehog Signaling in Mammary Gland Development and Breast Cancer. Hedgehog signaling and cancer therapeutic resistance.- Small-molecule Inhibitors of the Hedgehog Pathway.- Cyclopamine and its derivatives for cancer therapeutics.-.

• ISBN: 978-1-4419-8434-0
• Editorial: Springer New York
• Encuadernacion: Cartoné
• Páginas: 217
• Fecha Publicación: 08/05/2011
• Nº Volúmenes: 1
• Idioma: Inglés