The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms

The Molecular and Cellular Basis of Neurodegenerative Diseases presents the pathology, genetics, biochemistry, and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, chapters explore their pathogenic commonalities and differences, and also include discussion of animal models and prospects for therapeutics. The book uniquely presents diseases first, common mechanisms later - individual chapters discuss each major neurodegenerative disease, followed by chapters that integrate this information to offer multiple molecular and cellular mechanisms that these diseases may have in common, including protein misfolding, compromising protein degradation, disrupted axonal transport, dysfunctional mitochondria, toxic contributions by non-neuronal cells, RNA-mediated toxicity, and neuroinflammation. This book provides readers with a timely update on this rapidly advancing area of investigation and is invaluable for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical, and cellular featuresChapters focus on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegenerationDetails features, advantages, and limitations of animal models as well as prospects for therapeutics developmentAuthored by internationally recognized leaders in the fieldIncludes illustrations that help clarify and consolidate complex concepts INDICE: 1. General Overview 2. Prion Diseases 3. Alzheimer's Disease 4. Frontotemporal Dementia and Related Disorders 5. ALS and Other TDP43 Proteinopathies 6. Parkinson's Disease and Other Synucleinopathies 7. Huntington's Disease and Other Polyglutamine Disorders 8. Prion-like propagation in Neurodegenerative Diseases 9. Neurodegenerative Diseases as Protein Folding Disorders 10. Neurodegenerative Diseases and the Ubiquitin-Proteasome System 11. Neurodegenerative Diseases and Autophagy 12. Neurodegenerative Diseases and Axonal Transport 13. Neurodegenerative Diseases and Mitochondrial Dysfunction 14. Neurodegenerative Diseases and Non-cell autonomous toxicity 15. Neurodegenerative Diseases and RNA-mediated toxicity 16. Neurodegenerative Diseases and neuroinflammation 17. Neurodegenerative Diseases and Aging

• ISBN: 978-0-12-811304-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 500
• Fecha Publicación: 01/03/2018
• Nº Volúmenes: 1
• Idioma: Inglés