Arthropod Vector: Controller of Disease Transmission, Volume 2

Arthropod Vector: Controller of Disease Transmission, Volume 2: Vector Saliva-Host Pathogen Interactions is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 1: Controller of Disease Transmission, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures. The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host. These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes. Provides overviews of host defenses encountered by the blood feeding arthropod vector at the cutaneous interfaceAddresses how these defenses are modulated by the vector, specific functions of vector saliva components, host response to vector-borne infectious agents and how vector-borne pathogens themselves modulate host defensesFeatures expertly curated topics to ensure appropriate scope of coverage and aid integration of concepts and content across chapters INDICE: 1. Network of cells and mediators of innate and adaptive cutaneous immunity: challenges for an arthropod vector 2. Vector arthropods and host hemostasis 3. Vector Arthropods and Host Pain and itch responses 4. Arthropod Modulation of Wound healing 5. Sialomes: the molecular view of vector spit 6. Basic and translational research on sand fly saliva: pharmacology, biomarkers and vaccines 7. Unique features of vector-transmitted leishmaniasis and their relevance to disease transmission and control 8. Early immunological responses upon tsetse fly mediated trypanosome inoculation 9. Mosquito modulation of arbovirus-host interactions 10. Tick saliva as a modulator of host defenses 11. Tick saliva protein mitigation of Nod-like receptor sensing 12. Tsetse fly proteins as biomarkers of vector exposure 13. Epidemiological applications of assessing mosquito exposure in a malaria endemic area 14. Ixodes tick saliva: a potent controller at the skin interface of early Borrelia transmission 15. Translation of saliva proteins into tools to prevent vector-borne disease transmission 16. Translating basic research on arthropod vectors to products that can be applied in the field

• ISBN: 978-0-12-805360-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 332
• Fecha Publicación: 05/06/2017
• Nº Volúmenes: 1
• Idioma: Inglés