Arthropod Vector: Controller of Disease Transmission, Volume 1

Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures. The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host. These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes. Includes such major areas of coverage as host-derived factors, innate immunity of arthropod presentations and the arthropod microbiome/symbiontsFeatures expertly curated topics, ensuring appropriate scope of coverage and aid integration of concepts and contentProvides the necessary scientific background for the development of the research and discussions that have laid the groundwork for future efforts, including the Keystone Symposium and relevant meetings at NIAID/NIH INDICE: 1. The Site of the Bite: Addressing knowledge gaps in vector transmission of diseases 2. Conservation and convergence of immune signaling pathways with mitochondrial regulation in vector arthropod physiology 3. Wolbachia mediated immune inductions 4. Modulation of mosquito immune defenses as a control strategy 5. Molecular mechanisms mediating innate immune priming in Anopheles gambia 6. The impact of the vector microbiota on disease transmission 7. Using an endosymbiont to control dengue 8. Mosquitocidal properties of IgG antibodies that target glutamate-gated chloride channels of three 9. Role of microbiota during development of the arthropod immune system 10. Host-microbe interactions: A case for Wolbachia dialogue 11. Vector-microbiome interactions: impacts on mosquito immunity and development 12. Targeting Dengue Virus Replication in Mosquitoes 13. Paratransgenesis applications: fighting vector-borne pathogens with engineered symbionts 14. Two insulin-like peptides regulate resistance to Plasmodium falciparum infection in Anopheles stephensi

• ISBN: 978-0-12-805350-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 270
• Fecha Publicación: 05/06/2017
• Nº Volúmenes: 1
• Idioma: Inglés