Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targetsWritten for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicologyEdited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases INDICE: 1. Biometals and Alzheimer's Disease2. Copper in Alzheimer's Disease3. The Role of Selenium in Neurodegenerative Diseases4. Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?5. Chemical Elements and Oxidative Status in Neuroinflammation6. Metals and Neuroinflammation7. Metals and Prions: Twenty Years of Mining the Awe8. Manganese and Neurodegeneration9. Zinc in Autism10. Metals and Motor Neuron Disease11. Metals and Lysosomal Storage Disorders12. Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration13. Metal Biology Associated with Huntington's Disease14. Metal-Binding to Amyloid-ß Peptide: Coordination, Aggregation and Reactive Oxygen Species Production15. Metals and Mitochondria in Neurodegeneration16. Metal Transporters in Neurodegeneration17. Metal Imaging in the Brain18. Metalloregulation of Protein Clearance: New Therapeutics Avenues for Neurodegenerative Diseases19. Metals and Autophagy in Neurotoxicity20. An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases21. Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases

• ISBN: 978-0-12-804562-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 462
• Fecha Publicación: 01/06/2017
• Nº Volúmenes: 1
• Idioma: Inglés