Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods

Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Presents a complete review of molecular and cellar biology and immunology of Toxoplasma gondii combined with methods and resources for working with this pathogenProvides a single source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians and food scientistsCovers recent advances in the genomics, related bioinformatics analysis, epigenomics, gene regulation, genetic manipulation and proteomics of T. gondiiDetails advances in the molecular and cellular biology and immunology of Toxoplasma, and in the epidemiology, diagnosis, treatment and prevention of toxoplasmosis INDICE: 1. The History and Life Cycle of Toxoplasma gondii2. The Ultrastructure of Toxoplasma gondii3. Molecular Epidemiology and Population Structure of Toxoplasma gondii4. Human Toxoplasma Infection 5. Ocular Disease due to Toxoplasma gondii6. Toxoplasmosis in Wild and Domestic Animals7. Toxoplasma Animal Models and Therapeutics8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition 9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism 10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics11. The Apicoplast and Mitochondrion of Toxoplasma gondii12. Calcium Storage and Homeostasis in Toxoplasma gondii13. Signaling Networks in Toxoplasma gondii14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)17. Toxoplasma Host Effectors in Cell Interactions 18. Bradyzoite and Sexual Stage Development19. Development and Application of Classical Genetics in Toxoplasma gondii20. Genetic Manipulation of Toxoplasma gondii21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences25. Innate Immunity to Toxoplasma gondii26. Adaptive Immunity and Genetics of the Host Immune Response

• ISBN: 978-0-12-815041-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 1150
• Fecha Publicación: 01/03/2020
• Nº Volúmenes: 1
• Idioma: Inglés