Molecular genetics of liver neoplasia

Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking.Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy. The articles in this book provide an exciting overview of the most recent advances in the genetics and biology of liver cancer, their diagnosis, treatment and prevention. Contributions come from an international team of leading scientists and clinicians. Each chapter starts with a state-of-the-art topic, ranging from genetics and environmental risk factors of liver cancer, genetics of liver development and pathogenesis, genetics and epigenetic changes associated with liver cancer, the utilities of genetic animal models, cancer stem cells, gene expression profiling by microarrays and their relevance toliver cancer, to liver cancer genetics in the clinic. INDICE: Part I: Introduction 1. Overview of HCC: biology and pathology XinWei Wang, Joe Grisham and Snorri Thorgeirsson 2. Overview of CC: Part II: Liver development and pathogenesis 3. Embryonic development of the liver Kenneth S. Zaret 4. Human hepatic cell lineages Nelson Fausto 5. Pathology of Human Liver Cancer Masamichi Kojiro Part III: Genetics and epidemiology of liver cancer 6. HCC Hashem El.Serag 7. CC Greg Gores Part IV: Molecular Basis of Cancer Susceptibility 8. Yusuke Nakamura (NCC) 9. Hereditary liver diseases with a high risk to develop HCC Markus Grompe, [ALSO Marie-Annick Buendia] 10. Genetics and epigenetics of preneoplastic liver diaseses and human HCC 11. HBV: Jack Wands 12. HCV: Stanly Lemon 13. Fibrosis and cirrhosis studies David Brenner 14.Methylation status in chronic liver disease and HCC Yae Kanai (Japan) Part V.Animal models 15. Transgenic mouse models Snorri Thorgeirsson & Joe Grisham 16. Mosaic mouse model Scott Lowe 17. Zebrafish model Zhiyuan Gong (NUS): Part VI: Global gene expression profiling of human liver cancer 18. Integrativeand functional genomics of HCC Snorri Thorgeirsson: 19. Molecular signatures of metastatic HCC Xin Wei Wang 20. Liver cancer heterogeneity and tumor subtypes Jessica Rossi 21. Gene expression studies in cholangiocarcinoma Yoichi Furokawa Part VII: Cancer stem cells 22. Snorri Thorgeirsson 23. Tania Roskams Part VIII: Liver cancer genetics in the clinic 24. Biomarkers and clinical staging of liver cancer Josep Llovet 25. Molecular signaling in HCC Hong Yang Wang (Shanghai) 26. Molecular oncology and HCC Zhao-You Tang (Shanghai) 27. Molecular pathogenesis of HCC Irene Ig (Hong Kong)

• ISBN: 978-1-4419-6081-8
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 01/06/2010
• Nº Volúmenes: 1
• Idioma: Inglés