Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance bysuppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer. This book will discuss recent progress in innate immunity and Treg cells. This book will discuss the regulation of innate immunity through Toll-like receptor (TLR) signaling. Additionally, this book will offer an overview of recent developments in topics of cancer immunotherapy. INDICE: Immunosurveillance and Cancer. Innate Immune Responses in Cancer: NK, NKT, gamma-delta T cells. Toll-like Receptor Signaling in Immune Regulation. Targeting TLRs for Cancer Therapy. Immune Tolerance and Tumor Immunity. Regulatory T cells in Cancer. Control of Treg cells in Immunotherapy. Tumor Antigens recognized by T cells and Ab Yutaka Kawakami (Ag recognized by T cells). Current progress in cancer vaccine clinical trials. Adoptive T cell Therapy of Cancer. Clio Rooney and Helen Heslop (Lymphoma). Combination Therapy of Cancer---The Future of Cancer Treatment.
- ISBN: 978-1-4419-9913-9
- Editorial: Springer New York
- Encuadernacion: Cartoné
- Páginas: 300
- Fecha Publicación: 29/07/2011
- Nº Volúmenes: 1
- Idioma: Inglés