Quality of life outcomes in clinical trials and health-care evaluation: a practical guide to analysis and interpretation

With the recent attention paid to QoL in clinical trials and observation studies, many new QoL methods have been created. The majority of available QoL books tend to focus on detailed coverage of the design of these new QoL studies. This book differs in that it aims to assist the busy statistician/clinician inselecting the right QoL study methodology, and thus save them time in trial design. Readers are offered a practical guide to the use of already available QoL instruments as opposed to guidance on the designing of specific methods. The book then sets out to assist the reader in the accurate analysis and interpretation of QoL outcomes. It will examine the problems caused by QoL outcomes (which tend to generate data with discrete, skewed and bounded distributions) before presenting conventional methods to tackle such problems (e.g. linear regression). More advanced approaches are then discussed including ordinal regression and computer intensive methods (e.g. bootstrapping). Throughout the text the use of real life case studies and worked examples taken from the Authors own work will illustrate the methods discussed, and exercises and solutions will help further the readers experience. The book will also detail the use and implementation of the necessary software for statistical analysis, including SPSS, STATA and R. A supplementary website will also provide downloadable data files.

• ISBN: 978-0-470-75382-8
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 320
• Fecha Publicación: 25/09/2009
• Nº Volúmenes: 1
• Idioma: Inglés