Post-transcriptional regulation by STAR proteins: control of RNA metabolism in development and disease

This book aims to bring to the forefront a field that has been developing since the late 1990s called the STAR pathway for Signal Transduction and Activation of RNA. It is a signaling pathway that targets RNA directly; in contrast tothe canonical signal—kinase cascade—transcription factor—DNA—RNA. It is proposed to allow quick responses to environment changes such as those necessary inmany biological phenomenon such as the nervous system and during development." Reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets Overviews of the post?translational modifications of STAR proteins and their effects on biological functions Reviews what is known about STAR proteins and human disease including osteoporosis, schizophrenia, cancer, infertility and ataxia INDICE: STAR TREK: An Introduction to STAR Family Proteins and Review of QKI.- THE STAR FAMILY MEMBER: QUAKING (QKI) AND CEL SIGNALING.- INSIGHTS INTO THE STRUCTURAL BASIS OF RNA RECOGNITION BY STAR DOMAIN PROTEINS.- Post?translational Regulat ion of STAR Proteins and Effects on Their Biological Functions.- EXPRESSION AND FUNCTIONS OF THE star PROTEINS Sam68 AND t?star IN MAMMALIAN SPERMATOGENESIS.- The role of quaking in mammalian embryonic development.- Drosophila STAR Proteins: What Can Be Learned from Flies?.- C. ELEGANS STAR PROTEINS, GLD?1 AND ASD?2, REGULATE SPECIFIC RNA TARGETS TO CONTROL DEVELOPMENT.- THE BRANCHPOINT BINDING PROTEIN: In and Out of the Spliceosome Cycle.- Reachingfor the Stars: Linking Rna Binding Proteins to Diseases.

• ISBN: 978-1-4419-7004-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 162
• Fecha Publicación: 28/09/2010
• Nº Volúmenes: 1
• Idioma: Inglés