New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of the recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and to contribute to the increase in survival rate and well-being of patients are addressed. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment. It is a valuable resource for graduate students, oncologists, cancer researchers and members of biomedical field who need to learn more on recent developments on the management of glioblastoma. Provides guidance towards recent advances of new chemical entities and delivery strategies targeted to glioblastoma Includes overviews to help readers to apply the information in their research Encompasses summarizing diagrams and real-world examples to facilitate the comprehension and enhance the applicability of the content INDICE: I. Introduction A brief outlook into glioblastoma diagnosis and therapeutics II Diagnosis Biomarkers 1. Clinical practice guidelines for the management of GBM: a diagnosis perspective 2. Identification of Potential Biomarkers in Glioblastoma through Bioinformatic Analysis 3. Treading the way to new tissue biomarkers (microRNAs, Proteins, Small Molecules, Circulating Tumor Cells (CTCs), Extracellular Vesicles, Tumor Tissues, Biological Fluids 4. Circulating biomarkers in patients with glioblastoma 5. Glioblastoma extracellular vesicles: reservoirs of potential biomarkers? 6. Secretome analysis of patient-derived GBM cells for potential biomarker identification Techniques: updates 7. Newly Diagnosed Glioblastoma: A Review on Clinical Management 8. Combined PET/MRI in brain glioma imaging 9. Application of multi-wavelength technique for photoacoustic imaging in the GBM diagnosis 10. Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme 11. Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks III Therapeutics New chemical entities 12. Molecular Targeting of Glioblastoma: Drug Discovery and Therapies 13. Natural products: a hope for glioblastoma patients 14. The artificial intelligence contribution to speed-up the active compounds screening 15. Repurposing drugs in glioblastoma 16. Exploring new pathways: a cellular crosstalk approach 17. Study PI3K as a Key Target in Glioblastoma 18. Targeting DNA Damage Response Pathways in GBM, From Mechanistic Insights to Advances in the Clinic 19. The clinical trials landscape for glioblastoma New formulation approaches 20. An in-depth overview of current research strategies for glioblastoma treatment and barriers to progress 21. Empower the immune system to treat glioblastoma: DNA as medicine 22. Nanotechnology-based approaches in glioblastoma treatment 23. A MicroRNA based approach for the Treatment of Glioblastoma 24. The role of vaccines in glioblastoma - updated clinical results 25. A Complete Review of Autologous Dendritic Cells Loaded with Antigens from Self-Renewing Autologous Glioblastoma Cells 26. Cancer stem cells in glioblastoma 27. Optimizing the Role of Immunotherapy for Treatment of Glioblastoma 28. The role of exosomes in glioblastoma treatment IV Theranostics  29. Theranostic nanoparticles enhance the response of glioblastomas to radiation  30. System-based approaches as prognostic tools for glioblastoma  31. Data-driven biomarkers: the omics perspective  32. Theranostic strategies synergistically potentiate glioblastoma treatment via nanotechnology  33. The Effect of Glioblastoma Microenvironment on theranostics

• ISBN: 978-0-323-99873-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 600
• Fecha Publicación: 01/06/2023
• Nº Volúmenes: 1
• Idioma: Inglés