Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances

Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTB). The book examines the structure of pili shown under electron and atomic force microscopy and, by using whole genome sequencing, outlines the importance of pili in MTB. It also explores the role of pili in bacteria-host interactions and in drug development and delivery.The book provides an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. It also examines the structure of pili and the preparation of MTB for electronic and atomic microscopy. It explores the various life cycles of pili, the susceptibility patterns of MTB, the differences of pili formation in MTB, and their role in increase surveillance. It goes on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria-host interactions. Lastly, it explores the development of new drugs and their therapeutic delivery by pili. . Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTB. Introduces seven types of pili in MTB. Explains the mechanism of bacteria-host attachment and importance of this phenomena in MTB pili and other bacteria. Emphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells INDICE: About the authors 1. The structure and function of pili in bacteriaParissa Farnia, Poopak Farnia, Jalaledin Ghanavi and Ali Akbar Velayati1.1 The taxonomy of the genus Mycobacterium 1.2 Different pili in bacteria genies 1.3 The pili at genomic level 1.4 The role and function of pili in diseases References Further reading 2. The structure of pili under electron and atomic force microscopy Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi and Ali Akbar Velayati2.1 Preparation of Mycobacterium tuberculosis for electron microscopy 2.2 Preparation of Mycobacterium tuberculosis for atomic force microscopy 2.3 Preparation of different life cycle and susceptibility pattern of Mycobacterium tuberculosis2.4 Differences of pili formation in Mycobacterium tuberculosis and their role in increase surveillanceReferencesFurther reading3. The pili at genomic levelPoopak Farnia, Jalaledin Ghanavi, Jafar Aghajani, Saman Ayoubi, Saeid Besharati, Parissa Farnia and Ali Akbar Velayati3.1 Whole genome of Mycobacterium tuberculosis3.2 Genes related to pili expression and function in tuberculosis and other Mycobacterium speciesReferencesFurther reading 4. The design for drug delivery using pili in Mycobacterium tuberculosisJalaledin Ghanavi, Poopak Farnia, Jafar Aghajani, Saman Ayoubi, Saeid Besharati, Parissa Farnia and Ali Akbar Velayati4.1 Pili application in drug delivery in different bacteria4.2 Pili application in drug delivery in mycobacteriaReferencesFurther reading5. Role of Mycobacterium tuberculosis pili in hostParissa Farnia, Poopak Farnia, Jafar Aghajani, Saman Ayoubi, Saeid Besharati, Jalaledin Ghanavi and Ali Akbar Velayati5.1 The role of bacteria pili in host5.2 Role of Mycobacterium tuberculosis pili in hostReferencesFurther reading

• ISBN: 978-0-443-21712-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 340
• Fecha Publicación: 01/07/2024
• Nº Volúmenes: 1
• Idioma: Inglés