Caspases as Molecular Targets for Cancer Therapy discusses recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard-of-care and highlights numerous assay techniques for caspases activities. The book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspases types and their role in anticancer activity. In addition, it discusses caspases activity assay procedure and future perspectives. It is a valuable resource for researchers, students and members of the biomedical and medical fields who want to learn more about novel anticancer targeted therapies. Discusses caspases thoroughly, including its mechanism of action and the mutation responsible for the development of cancerPresents updated literature of synthetic compounds for the development of caspases mediated new anticancer drugsEncompasses comprehensive compilation of recently introduced anticancer drugs in the market, health outcomes, and Pharmacoeconomics INDICE: 1. Introduction to Caspases, its function, mechanism, and classification2. Mutations within apoptosis gene and caspases3. Inflammatory caspases -1, -4, and -5 and their role in anticancer activity4. Caspase-2 and tumor suppression5. Caspase-3: A promising target for anticancer agents6. Caspase-7 mutations and its activators7. Re-instating the expression and activation of caspase-8 and caspase-10 in cancer therapy8. Caspase-9 gene mutation and its activators9. Caspases activity assay procedure10. Current and future prospective of caspases targeting in cancer therapy
- ISBN: 978-0-443-15644-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 300
- Fecha Publicación: 23/09/2024
- Nº Volúmenes: 1
- Idioma: Inglés