The Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology and cancer, but also goes beyond by connecting the interface of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and development of this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research, The Ecology and Evolution of Cancer is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as lecturers in evolutionary medicineFunctions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributorsImproves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystemsHighlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies INDICE: 1. Introductory chapter - Cancer as an ecological and evolutionary process? 2. Evolutionary origin of cancer 3. Cancer in the animal kingdom 4. Evolution and ecology of transmissible cancers with underlying pathogen infection 5. Life at the Edge: Tumour Stromal Interactions Driving Cancer Evolution 6. The genomic landscapes of cancers 7. The role of epigenetics in cancer evolution 8. Anti-cancer mechanisms 9. Co-evolution of tumour cells and their microenvironment 10. Immune system and cancer 11. The response of cancer cell populations to therapies 12. Ecology of metastatic process 13. Ecology and evolution of transmissible cancers with non-underlying pathogen infection 14. The role of cancer in ecosystem functioning 15. Applying tools from evolutionary biology to cancer research Perspectives 16. Perspectives: uni vs multicellularity - cancer evolution on a broader scale 17. Perspectives: atavism theory - cancer evolution on a broader scale 18. Perspectives: tumour evolution 19. Perspectives: tumour ecosystem - tumour evolution 20. Perspectives: angiogenesis - tumour evolution 21. Perspectives: dormancy - tumour evolution 22. Perspectives: tumour and host evolution 23. Perspectives: super organism - host evolution 24. General Conclusion
- ISBN: 978-0-12-804310-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 416
- Fecha Publicación: 10/03/2017
- Nº Volúmenes: 1
- Idioma: Inglés