Heart rate and rhythm: molecular basis, pharmacological modulation and clinical implications

Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca²⁺ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a reviewof established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells. Of interest for researchers in cardiac electrophysiology, cell biology, and pharmacology INDICE: Normal Cardiac Rhythm and Pacemaker Activity. Modeling of Rhythm in the Heart. Cardiac Development and Anatomy. Mechanisms of Acquired Arrhythmia. Mechanisms of Inherited Arrhythmia. Role of Specific Channels and Transporters in Arrhythmia. Drugs and Cardiac Arrhythmia.

• ISBN: 978-3-642-17574-9
• Editorial: Springer Berlin Heidelberg
• Encuadernacion: Cartoné
• Páginas: 680
• Fecha Publicación: 01/03/2011
• Nº Volúmenes: 1
• Idioma: Inglés