Advances in Prodrugs: Design and Therapeutic Applications

Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases. Highlights chemistry and pharmacology-related aspects, offering a versatile tool for readers involved in prodrug development and studyDiscusses in-depth treatment of several activation mechanisms and applications for disease treatmentsCovers a range of topics from basic contents, design, and mechanisms of actions to current applications in drugs INDICE: Part 1 Introduction1. Prodrugs: general concepts, prodrug design in medicinal chemistryPart 2 activation mechanisms and related functional groups2. Ph-sensitive prodrugs3. Enzyme-mediated activation of prodrugs4. Reactive oxygen species-responsive prodrugs5. Photoactivable prodrugs6. Antibody directed enzyme prodrug therapy (adept)7. Self-assembling prodrugs8. Carrier-linked prodrugs9. Hypoxia-activated prodrugsPart 3 application of prodrugs in the treatment of diseases10. Antiviral and antiretroviral prodrugs11. Prodrugs for cancer therapy12. Prodrugs for neurodegenerative diseases13. Prodrugs in cardiovascular therapy14. Prodrugs for inflammatory diseases15. Prodrugs for ocular diseases16. Antibacterial prodrugs17. Prodrugs against neglected diseases

• ISBN: 978-0-443-15635-9
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 350
• Fecha Publicación: 01/09/2024
• Nº Volúmenes: 1
• Idioma: Inglés