Solid-phase organic synthesis: concepts, strategies, and applications

INDICE: Preface. Acknowledgements. Contributors. Part I. Concepts and Strategies. 1. Linker Strategies in Modern Solid-Phase Organic Synthesis (Peter J. H. Scott). 1.1 Introduction. 1.2 Classical Linker Strategies. 1.3 Multifunctional Linker Strategies. 1.4 Conclusions. 2. Colorimetric Tests for Solid-Phase Organic Synthesis (Yan Teng and Patrick H. Toy). 2.1 Introduction. 2.2 Functional Group Tests. 2.3 Conclusions. 3. Practical Aspects of Combinatorial Solid-Phase Synthesis (Jan Hlvá , Miroslav Slural and Viktor KrchHák). 3.1 Introduction. 3.2 Strategies in Combinatorial Solid-Phase Synthesis. 3.3 Equipment and Instrumentation. 3.4 Characterization and Purification. 3.5 Conclusions. 3.6 Acknowledgements. 4. Diversity-Oriented Synthesis (Kieron M. G. OConnell, Warren R. J. D. Galloway, Brett M. Ibbeson, Albert Isidro-Llobet, Cornelius J. OConnor and David R. Spring). 4.1 Introduction. 4.2 Small Molecules and Biology. 4.3 Diversity-Oriented Synthesis, Target-Oriented Synthesis and Combinatorial Chemistry. 4.4 Molecular Diversity. 4.5 Diversity-oriented Synthesis on Solid-Phase. 4.6 Diversity-Oriented Synthesis Around Privileged Scaffolds. 4.7 Diversity Linker Units in Solid-Phase Organic Synthesis. 4.8 Conclusions. 5. Diversity-Oriented Synthesis of Privileged Heterocycles Using Divergent Strategy (Seung Bum Park and Jonghoon Kim). 5.1 Introduction. 5.2 Divergent Synthesis of Natural Product-Like Polyheterocycles Using a Cyclic-Iminium as a Single Key Intermediate. 5.3 Conclusions. 6. Chemo- and Regioselectivity Enhancement in Solid-Supported Reactions (Douglas D. Young and Alexander Deiters). 6.1 Introduction. 6.2 Transition Metal-Mediated Solid-Supported Reactions. 6.3 Non-Transition Metal-Mediated Solid-Supported Reactions. 6.4 Traceless Cleavage. 6.5 Conclusions. Part II. Applications. 7. Asymmetric Synthesis on Solid-Support (Baburaj Baskar and Kamal Kumar). 7.1 Introduction. 7.2 Asymmetric Chemical Transformations of Solid-Supported Substrates. 7.3 Asymmetric Transformations Using Bound Chiral Catalysts and Auxiliaries. 7.4 Conclusions. 8. Recent Advances in Microwave-Assisted Solid-Phase Synthesis of Heterocycles (Prasad Appukkuttan, Vaibhav P. Mehta and Erik Van der Eycken). 8.1 Introduction. 8.2 Fused 1, 3-Oxazin-6-ones. 8.3 Thiazolo[4,5-d]pyrimidine-5,7-diones. 8.4 Pyrazoles. 8.5 Hsp70 Modulators. 8.6 Benzimidazo[2,1-b]quinazolin-12(5H)-ones. 8.7 Imidazoles. 8.8 1,4-Napthoquinones. 8.9 Phthalocyanines. 8.10 1,2,3,4-Tetrahydroquinolines. 8.11 1,2,3-Triazoles. 8.12 2,8-Diaminopurines. 8.13 Imidazolidin-4-ones. 8.14 Indoles. 8.15 1,2,3,4-Tetrahydroquniolines Using a SmI2-Cleavable Linker. 8.16 Hydantoins. 8.17 Imatinib. 8.18 Isoindolines. 8.19 2-(Benzothio)imidazo[1,2a]-pyrimidin-5-ones. 8.20 2-Aminobenzothiazoles. 8.21 Pyrimidines, Phrazoles and Isoxazoles. 8.22 Quinolin-2(1H)ones and Coumarins. 8.23 Benzofurans. 8.24 i-Condensed Purines. 8.25 2(1H)-Pyrazinones. 8.26 Conclusions. 9. Solid-Phase Synthesis of Heterocycles from Peptides and Amino Ac

• ISBN: 978-0-470-59914-3
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 568
• Fecha Publicación: 27/01/2012
• Nº Volúmenes: 1
• Idioma: Inglés