Carbohydrates in Drug Discovery and Development: Synthesis and Application

Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent, important developments in synthesis, biology, and biomedical applications of carbohydrates as well as therapeutic and pharmacological aspects of carbohydrate chemistry. Structural aspects of carbohydrates make this moiety efficiently able to form diverse linkages, substitutions, and branching patterns which have attracted generations of chemists towards harnessing these properties. In addition to the advancement in construction of oligosaccharides, chemists are also making strides in the ability to assemble glycopeptides and glycoproteins. These are important synthetic targets, not only from a basic research standpoint but also because they play essential biological roles. Carbohydrates are one of the most challenging classes of biomolecules in terms of synthesis, structure, and biological implications. This book covers advanced aspects of carbohydrates, starting with a brief introduction, nomenclature, and classification, followed by a discussion of glycosidic bond formation methodology, recent protocols for the synthesis of O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), carbohydrate modification, as well as standard protection-deprotection techniques in carbohydrate chemistry. Written by a team of international experts actively working on different aspect of synthetic carbohydrate chemistry, this book is an invaluable resource for carbohydrate chemists, natural products chemists, medicinal chemists, synthetic organic chemists and biochemists working in industry and academia. Gives a practical, detailed overview of a wide range of carbohydrate systems relevant for drug discovery and developmentHighlights applications of functionalized carbohydrates and their use as synthons for the construction of various systemsCovers recent developments in the synthesis of various glycohybrid molecules INDICE: 1. Recent Trends and Challenges on Carbohydrate-based Molecular Scaffolding: General Consideration towards Impact of Carbohydrates in Drug Discovery and Development2. Carbohydrate-protein Interactions: Enhancements through Statistical Rebinding3. Imino Sugars in Medicinal Chemistry4. Recent Developments in the Synthesis of Inositol Derivatives5. Sialic Acids in Drug Discovery and Development6. Glycan Microarrays in Drug Discovery and Development7. Carbohydrate-based Antibiotics: Opportunity and challenges 8. Carbo-Click in Drug Discovery and Development9. Recent Developments on Synthesis and Bioactivity of C-glycosylated Compounds10. Glycohybrids Molecules in Pharmaceutical Industry: Recent Advancement and Future Prospective11. Biologically Active Carbohydrate-based Macrocycles 12. Carbohydrate based Antibacterial and Anticancer Vaccines13. Opportunity of Plant Oligosaccharides and Polysaccharides in Drug Development 14. 3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) Derivatives in Antibacterial Drug Discovery15. N-acetylgalactosamine (GalNAc) - Conjugates: Delivering Oligonucleotide Drugs to the Liver16. Recent Advances in Glyconanoparticles Aided Therapy and Diagnosis

• ISBN: 978-0-12-816675-8
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 700
• Fecha Publicación: 01/08/2020
• Nº Volúmenes: 1
• Idioma: Inglés