The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This book is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. Provides an overview of the pharmacology of the four histamine receptors and describes how histamine is synthesized and the insights derived from mice where this synthesis is disrupted. Discusses the important role of histamine inneurotransmission and for the treatment of various neurological disorders. Explains the future of antihistamine research and the potential for novel antihistamines targeting the newest members of the histamine receptor family—the H3 and H4 receptors. INDICE: One Hundred Years of Histamine Research. Molecular Pharmacology ofthe Four Histamine Receptors. Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient Mice. Histamine in Allergic Rhinitis. The Roleof Histamine in Ocular Allergy. The Role of Histamine in Asthma. Antihistamines in the Treatment of Urticaria. Histamine and Antihistamines in Atopic Dermatitis. Histamine, Immune Cells and Autoimunity. Histamine in Neurotransmisi onand Brain Diseases. Histamine in Normal and Malignant Cell Proliferation. TheFuture Antihistamines: Histamine H3 and H4 Receptor Ligands.
- ISBN: 978-1-4419-8055-7
- Editorial: Springer US
- Encuadernacion: Cartoné
- Páginas: 144
- Fecha Publicación: 28/04/2011
- Nº Volúmenes: 1
- Idioma: Inglés