Natural killer T cells: balancing the regulation of tumor immunity

This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells. Natural killer T (NKT) cells discussed in this book are CD1d-restricted T cells. Overview of structures and functions of glycolipid antigens. Explains roles of NKT cells in human lymphoma patients. INDICE: Preface.- Introduction: Mechanisms of NKT cell-mediated adjuvant activity and function of iPS-derived NKT cells. Structure and Recognition of Antigens for Invariant NKT Cells. Invariant NKT cell-based vaccine strategies. Immune regulation of tumor immunity by NKT cells. The Regulation of CD1d+ and CD1d- tumors by NKT Cells. DC-based immunotherapy targeting NKT cells. Therapeutic Approaches Utilising NKT Cells. NKT Cells of Cancer Patients & How Modelscan Inform Therapeutic Plans. Understanding the role of Natural Killer T (NKT) cells in hematologic malignancies: progress and challenges. Clinical trials with ?-galactosylceramide (KRN7000) in advanced cancer. Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer. Index. .

• ISBN: 978-1-4614-0612-9
• Editorial: Springer New York
• Encuadernacion: Cartoné
• Páginas: 229
• Fecha Publicación: 28/10/2011
• Nº Volúmenes: 1
• Idioma: Inglés