Viruses: Molecular Biology, Host Interactions and Applications to Biotechnology

Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal, and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that the world of viruses is vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view of the tree of life and their inherent and derived 'interactomics', as defined by the molecules and the processes by which virus gene products interact with themselves and with the host's cellular gene products to bring about changes in phenotypes. Further, it includes perspectives on basic aspects of virology including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses. Provides key insights into recent technological advances, including high-throughput sequencingPresents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of lifeFeatures exposition on the diversity and versatility of viruses, how they cause disease, and explores virus-host interactions INDICE: Section 1. Virus biology, taxonomy, replication and host interactions 1. Introduction. A short history along with the reasons why viruses are studied and used 2. Structure and Taxonomy. Types (nucleic acids) and organization of virus genomes and how these two factors define Virus Taxonomy 3. Replication and expression strategies. Strategies of expression exploited by viruses, many of which are not utilized by cellular organisms 4. Origin and evolution of viruses. Recently discovered viruses, hypotheses of virus origin and evolution 5. Virus- host interactions, virus transmission and emerging diseases. The three areas will be presented separately, with emphasis on how the first two define the latter 6. Host resistance and pathogen virulence. Explanations of the molecular mechanics of viral diseases 7. Diagnosis and management of virus diseases. Ways by which viruses are detected, characterized and controlled/managed-if not avoided Section 2 Viruses as pathogens, symbionts and tools for biotechnology 8. Viruses as Pathogens 9. Viruses as Symbionts 10. Viruses as Tools for Biotechnology: Therapeutic agents, carriers of therapeutic agents and genes

• ISBN: 978-0-12-811257-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 320
• Fecha Publicación: 01/03/2018
• Nº Volúmenes: 1
• Idioma: Inglés