The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post?translational modifications, degradation and turnover, and how they define and influence aging. The chaptersmainly focus on well?characterized factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Illustrates that aging cells are characterized by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation is controlled at multiple levels Discusses paradoxical situation of autophagy up?regulation in models of premature aging Roleof mitochondria in protein quality control and the influence of reactive oxygen species INDICE: Synthesis, Modification and Turnover of Proteins during Aging.- Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control.- Protein Synthesis and the Antagonistic Pleiotropy Hypothesis of Aging.- Proteasome Function Determines Cellular Homeostasis and the Rate of Aging.- Autophagyand Longevity: Lessons from C. elegans.- Autophagy and Aging: Lessons from Progeria Models.- Regulation of Protein Turnover by Longevity Pathways.- ProteinMetabolism and Lifespan in Caenorhabditis elegans.- Mitochondrial Protein Quality Control Systems in Aging and Disease.- p38MAPK in the Senescence of Humanand Murine Fibroblasts.- Protein Homeostasis in Models of Aging and Age?Related Conformational Disease.- Roles for SUMO Modification during Senescence.- Post?Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin?Like Molecules: Role in Cellular Senescence and Aging.- Sensory Influence on Homeostasis and Lifespan: Molecules and Circuits.- Regulation of Muscle Atrophyin Aging and Disease.- Confronting Cellular Heterogeneity in Studies of Protein Metabolism and Homeostasis in Aging Research.
- ISBN: 978-1-4419-7001-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 248
- Fecha Publicación: 28/09/2010
- Nº Volúmenes: 1
- Idioma: Inglés