The volume focuses on therapeutic targets that were identified after TNF blockade and that have recently been registered or are currently under developmentfor the treatment of rheumatoid arthritis. Each chapter discusses the biological rationale in great detail, including in vitro work and work in animal models, and where appropriate, results form clinical trials. The book is written by an international authorship of experts in this field. It is of interest to rheumatologists, immunologists, internists, investigators in immunology and rheumatology, the pharmaceutical industry. Focuses on therapeutic targets that were identified after TNF blockade and that have recently been registered or arecurrently under development. INDICE: From the contents B cells (rituximab, anti-Blyss, TACI-Ig).- Co-stimulatory pathways (abatacept and others).- L-6R.- Oncostatin-M.- Il-1.- IL-12/IL-23.- IL-15.- IL-17.- IL-18.- IL-10 related cytokines.- Chemokines.- Signaling pathways.- Osteopontin.
- ISBN: 978-3-7643-8237-7
- Editorial: Birkhaüser
- Encuadernacion: Cartoné
- Páginas: 250
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés