Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases

The complex microbial communities that inhabit most external human surfaces play a key role in health and diseases. Perturbations of host-microbe interactions can lead to altered host responses that increase the risk of pathogenic processes and promote disorders such as inflammatory bowel diseases, cancers, obesity, diabetes, autism, and asthma. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. 

In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. Organoids recapitulate essential features of the in vivo tissue architecture. It can be greatly expanded while maintaining intact stem cell compartments during long-term culture. This relatively simple system will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the application of organoids in studying microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.