Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties.  This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki's book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. Examines the evolutionary origins and consequences of the extracellular matrix Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learningProvides an introduction to the properties and organization of the extracellular matrix components INDICE: 1. Introduction and overview of the extracellular matrix and its relation to cells2. Building blocks, evolution and organization of collagen from amino acids to fibrous tissue3. Functional properties of collagen from molecules to tissue in normal and diseased states: interpretation with analytic and computational models4. Building blocks, evolution and organization of elastin from amino acids to fibrous tissue5. Functional properties of elastin from molecules to tissue in normal and diseased states: interpretation with the use of modeling6. Building blocks, evolution, organization and function of microfibrils7. Mechanical properties of microfibrils and their roles in development and disease8. Building blocks, evolution, organization and function of proteoglycans9. Mechanical and electrical properties of proteoglycans and their relation to other extracellular proteins: computational modeling10. Relation of the extracellular matrix components to each other and cells: mechanical interactions and mechanotransduction11. Extracellular matrix homeostasis: modeling the mechanical properties of single molecules, fibrils and fibers12. Modeling the mechanical properties of network of fibrils and fibers embedded in proteoglycans13. Basic concepts in multiscale modeling: examples of tendon, vessels, lung and cartilage14. Modeling the repair and digestion of fibers and networks15. General multiscale modeling of tissue failure: implications for tendon rupture, aneurysm and emphysema16. Application of mathematical modeling to tissue engineering and regenerative medicine

• ISBN: 978-0-12-819716-5
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 250
• Fecha Publicación: 01/12/2020
• Nº Volúmenes: 1
• Idioma: Inglés