The Chemistry of Hyperpolarized Magnetic Resonance Probes

The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included. Helps readers understand the structural features that determine the properties of HP-probes, such as chemical shift and relaxation times Aids readers in selecting stable isotope labeled probes for hyperpolarized NMR/MRI applications Teachers readers how to use the most appropriate synthetic methodology for the labeled probes Covers how to find the most suitable polarization technique (DNP, PHIP etc.) for the probe INDICE: 1. Hyperpolarized tracer design, synthesis and characterization2. Glassing matrices and optimization of solid-state polarization in dynamic nuclear polarization (DNP)3. Free radical polarizing agents for DNP4. The chemistry of parahydrogen induced polarization (PHIP)5. Hyperpolarized imaging techniques for small animal studies

• ISBN: 978-0-323-91842-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 200
• Fecha Publicación: 01/11/2022
• Nº Volúmenes: 1
• Idioma: Inglés