Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment

Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Children, who have not yet stopped growing, experience excessive growth known as gigantism. Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment brings together pituitary experts from all areas of research and practice, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches to manage these rare disorders. This serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, other clinicians, including pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable. There are many review articles on the topic of acromegaly and gigantism, but the range of topics is limited. This reference provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as a recommended approach to evaluation and management written by internationally recognized experts. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantismUnique compendium of endocrinology, genetics, clinical diagnosis, and therapeuticsInternationally known experts who have treated patients with acromegaly and gigantism INDICE: 1. History of the identification of gigantism and acromegaly by Patrick PETROSSIANS ((NEW chapter added from reviewer comments.) 2. Pathology of Pituitary Adenomas Secreting Growth Hormone by Sylvia Asa 3. Gigantism: Clinical Diagnosis and Description by Albert Beckers 4. Acromegaly: Clinical Diagnosis and Description by Ashley Grossman 5. Neuroimaging in gigantism and acromegaly by George Papadakis & Nick Patronas (NEW chapter added from reviewer comments.) 6. X-linked Acro-gigantism : by Giampaolo Trivellin 7. AIP Defects (Aryl hydrocarbon receptor interacting protein): by Laura Hernandez-Ramirez 8. 3-PAs : by Paraskevi Xekouki 9. CDKNIB (p27) defects by Natalia Pellegata and/or Marily Theodoropoulou 10. Multiple Endocrine Neoplasia (MENs) and pituitary tumors by Sunita Agarwal and/or S. Marx 11. GNAS, McCune-Albright syndrome, and GH-producing tumors by Anna Spada 12. Neurosurgical aspects of pit tumor secreting GH by Prashant Chittiboina 13. Irradiation and/or medical treatment of gigantism and acromegaly by Maria Fleseriu 14. Growth Hormone Releasing Hormone - producing and other tumors leading to overgrowth by Amit Tirosh and/or Maya Lodish 15. Increased GH secretion and non-pituitary tumors: is there an association? By Michael T. Collins ((NEW chapter added from reviewer comments.)

• ISBN: 978-0-12-814537-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/02/2021
• Nº Volúmenes: 1
• Idioma: Inglés