Targeted radionuclide tumor therapy: biological aspects

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title ofthis book ‘Targeted Radionuclide Tumor Therapy – Biological aspects’ was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future Focus on biological effects of targeted radionuclide therapy Comprehensive presentation of different mechanisms of tumor cell death Up-to-datepresentation of new targeting agents Summaries of present state of clinical applications of targeted therapy Introduction of the new concept; Autosensitization during radionuclide therapy INDICE: From the contents 1. Introduction to radionuclide therapy 2. Therapeutically used antigens in radioimmuno therapy 3. Egfr-family expression and implications for targeted radionuclide therapy 4. Targeting tumors with radiolabeled antobodies 5. Antobody fragments produced by recombinant and proteolytoc methods 6. Novel alternative scaffolds and their potential use for tumor targeted radionuclide therapy 7. Peptides for radionuclide therapy 8. Choice of radionuclides and radiolabelling techniques 9. High-let-emitting radionuclides for cancer therapy 10. Targeted high-let therapy of bone metastases 11. The auger effect in molecular targeting therapy 12. Radiation induced cell deaths 13. Radiation induced dna-damage/repair and associated signaling pathways 14. Radiation induced dna damage checkpoints 15. Cancer stem cells and radiation 16.Effects of low dose-rate radiation on cellular survival 17. Bystander effectsand radionuclide therapy 18. Enhancing the efficiency of targeted radionuclide treatment .

• ISBN: 978-1-4020-8695-3
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 470
• Fecha Publicación: 01/10/2008
• Nº Volúmenes: 1
• Idioma: Inglés