Oxidation: the cornerstone of carcinogenesis. Oxidation and tobacco smoke carcinogenesis : a relationship between cause and effect

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive texton the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. Subject matter is comprehensive and complete. Includes 1880 up-to-date relevant references divided at the end of each chapter. Interconnects chapters of three major topics: Oxidative stress, tobacco smoke toxicity, and carcinogenesis INDICE: 1: Oxygen and Nitrogen free radicals. 2: Oxidative stress. 3: Oxidative damage of genome DNA: repair mechanisms. 4: Mitochondria: structure, function and relationship with carcinogenesis. 5: Oxidative activation of transcription factor pathways by cigarette smoke oxidants. 6: Cell protection mechanisms from oxidation. 7: Role of DNA adducts in carcinogenesis. 8: Transmolecular reactions of genetic toxicity: alkylation and methylation of DNA. 9: Toxicity and carcinogenicity of hydrocarbons. 10: Toxicity and carcinogenicity of thearomatic hydrocarbons. 11: Toxicity and carcinogenicity of aldehydes. 12: Toxicity and carcinogenicity of the nitriles. 13: Toxicity and carcinogenicity ofthe eterocyclic organic compounds. 14: Toxicity and carcinogenicity of metals. 15:Oxidative profile of cigarette smoke and lung cancer. 16: Smoking and lung cancer.

• ISBN: 978-1-4020-6703-7
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 258
• Fecha Publicación: 01/01/2008
• Nº Volúmenes: 1
• Idioma: Inglés