T Cell Metabolism and Cancer Immunotherapy investigates the cellular regulation of T-cell immunity and tolerance. Within ten chapters, the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy. Because of the plasticity and potentially unlimited capacity for self-renewal, stem cell-derived T lymphocytes have great potential in the treatment of diseases, including cancer.?Despite great advancement in immunotherapy, such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy.? Provides a summary of the current state-of-the-art, creating a valuable foundation for both established researchers and newcomers/students in the field of cancer immunotherapiesFocuses on the investigation of cellular regulation of T-cell immunity and toleranceDefines the precise role and mechanism of T cell metabolism in modulating T cells and T cell-mediated immunityPresents insights to develop and optimize strategies for utilizing highly reactive T lymphocytes for cell-based therapies INDICE: 1. The role of T Cell Metabolism in Cancer Immunotherapies2. Pancreatic cancer immunotherapy using childhood vaccine recall antigens and Listeria3. Targeting MyD88 costimulation in cancer immunotherapy4. T cell-derived IL-27 for cancer immunotherapy5. Defeating cancer with immunomodulatory bacterial therapeutics6. Salmonella-based cancer immunotherapy: current progress and prospects?7. Cancer immunotherapy for hepatocellular carcinoma8. Integrative targeted therapy for melanoma9. Controls of memory T cell differentiation10. Inhibition of the Wnt/ß-Catenin Pathway overcomes prostate cancer resistance
- ISBN: 978-0-443-13827-0
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 220
- Fecha Publicación: 01/09/2024
- Nº Volúmenes: 1
- Idioma: Inglés