Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disorders summarizes recent developments in intervention trials in neurodegenerative disorders, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic syndrome and neurodegenerative disorders that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include mitochondrial and endosomal-lysosomal dysfunction and bioenergetic defects in neurodegenerative disorders, the link between ApoE-4/?-synuclein in metabolic and neurodegenerative disorders from a metabolic perspective, the potential role and repurposing of SGLT2Is and GLP1 agonists for neurodegenerative disorders, and other novel directions of research for innovative therapeutic strategies for neurodegenerative disorders like ketotherapeutics and intermittent metabolic switching lifestyles. Covers the latest evidence on the commonalities of neurodegenerative disorders and metabolic diseaseSummarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative disordersPresents the novel treatment strategies based on the metabolic hypothesis for neurodegenerative disorders INDICE: SECTION 1: HISTORICAL OVERVIEW OF NEURODEGENERATIVE DISORDER RESEARCH AND COMMONALITIES WITH METABOLIC DISEASE 1. Status and Future Directions of Clinical Trials in Alzheimer's Disease George Perry 2. Status and Future Directions of Clinical Trials in Parkinson's Disease Grazyna Soderbom 3. Tracking the Potential Involvement of Metabolic Disease in Neurodegenerative Disorders - Biomarkers and Beyond Jose Luchsinger 4. Brain Cells Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Disorders Dimitrios Kapogiannis 5. Role of Senescence in Aging and Aging-Related Disease with Emphasis on and Implications for Neurodegenerative Disorders James Kirkland and Erin Wissler Gerdes SECTION 2: A MECHANISTIC APPROACH TO NDDS AND THE METABOLIC HYPOTHESES 6. Evidence for Pathophysiological Commonalities between Metabolic and Neurodegenerative Disorders Christian Hölscher 7. Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Disorders Paul Edison 8. GABA-ergic Interneuron Dysfunction and Neuronal Network Hyperexcitability in Neurodegenerative Disorders MARK MATTSON 9. The Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects and the Metabolic Link to Alzheimer's Disease Russell Swerdlow 10. Mitochondrial and Endosomal-Lysosomal Dysfunction and Bioenergetic Defects in Parkinson's Disease and Metabolic Disorders ole Isacson 11. Endosomal-Lysosomal Dysfunction in Metabolic Disorders and Alzheimer's Disease Ben A. Bahr 12. Oxidative Stress and Damage in Metabolic and Neurodegenerative Disorders: the role of IL6 & the Inflammasomes Grazyna Soderbom 13. Disturbances in Brain Energy Metabolism in Insulin Resistance and Diabetes and Alzheimer's Disease - Learnings from Brain Imaging and Biomarkers Kerstin Heurling 14. Dysregulation of Metabolic Flexibility: the Impact of mTOR on Autophagy in Neurodegenerative Disorders Kenneth Maiese 15. Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Disorders Erik S. Musiek 16. The Impact of Neurovascular Dysfunction, the Endothelial Cell and Blood-Brain Barrier, and Glymphatic System Regulation in Metabolic and Neurodegenerative Disorders Jeffrey Iliff 17. Is There a Link Between ApoE-4/a-SYN in Neurodegenerative Disorders and Metabolic Disorders from a Metabolic Perspective? Lance Johnson SECTION 3. TREATING METABOLIC DISEASE IN BODY AND BRAIN 18. Insulin in Alzheimer's Disease and Parkinson's Disease Therapy and Risk Reduction by Repurposing Metformin and Thiazolidinediones Paula Moreira 19. Repurposing GLP1 Agonists for Neurodegenerative Disorders Per Svenningsson 20. Role of the SGLT2Is in Metabolic and Neurodegenerative Disorders Russell Esterline 21. Ketotherapeutics for Neurodegenerative Disorders Kieran Clarke 22. Intermittent Metabolic Switching Lifestyles (Exercise and Fasting) to Forestall Neurodegenerative Disorders MARK MATTSON 23. Restoring Defective Mitophagy in Neurodegenerative Disease Evandro F. Fang 24. Harnessing Neurogenesis in Adults - A Role in Metabolic and Neurodegenerative Disorders Orly Lazarov 25. Hormesis: a Therapeutic Approach for Neurodegenerative Disorders? Edward J. Calabrese 26. Beyond Beta Amyloid; C99 as a Likely Driver and Target in the Pathogenesis of Alzheimer's Disease. Estela Area-Gomez

• ISBN: 978-0-12-820076-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 322
• Fecha Publicación: 10/08/2020
• Nº Volúmenes: 1
• Idioma: Inglés