Fueled by the expertise of a team of international specialist authors, this overview captures everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part of the book systematically surveys known and suspected drug targets within the epigenetic machinery, including coverage of the first successful drug candidates available for these novel targets. An outstanding contribution covers the discovery of the first-ever marketed epigenetic drug (Vorinostat), discovered at the Merck oncology labs in Boston.
- ISBN: 978-3-527-32355-5
- Editorial: Wiley-VCH
- Encuadernacion: Cartoné
- Páginas: 312
- Fecha Publicación: 24/06/2009
- Nº Volúmenes: 1
- Idioma: Inglés