This book will be the first to leverage on recent breakthroughs in the rapid,high-throughput molecular profiling of pathogenic microorganisms, as well as text mining and the growing body of electronic sources of knowledge about the molecular epidemiology of pathogens with epidemic potential. The distinctive feature of this book is that its focus on bioinformatics enabled approaches to pathogen detection, investigation and management of infections. This volume also details new methods of analyzing the genetic and geographic data of pathogens to reconstruct their evolution and to identify the migration routes throughwhich the strains spread regionally and internationally. This book will fill the existing gap in covering the bioinformatics aspects of infectious diseasesand will complement numerous successful bioinformatics texts devoted to the mainstream of human genetics and cancer. Recent breakthroughs in rapid, high-throughput molecular profiling of pathogenic microorganisms Focus bioinformaticsenabled approaches to pathogen detection, investigation and management of infections New methods of analyzing genetic and geographic data of pathogens to reconstruct evolution and identify migration routes where strains spread Fills gap in bioinformatics aspects of infectious diseases and complements bioinformatics texts devoted to the mainstream of human genetics and cancer INDICE: Preface.- List of contributors.- 1 Informatics for Infectious Disease Research and Control.- 2 Bioinformatics of Microbial Sequences.- 3 Mining Databases for Microbial Gene Sequences.- 4 Comparative Genomics of Pathogens.-5 Systems Microbiology: Gaining Insights in Transcriptional Networks.- 6 Host-Pathogen Systems Biology.- 7 Text Mining for Discovery of Host-Pathogen Interactions.- 8 A Network Approach to Understanding Pathogen Population Structure:from Host Networks to Antigen Networks.- 9 Computational Epitope Mapping.- 10Pangenomic Reverse Vaccinology.- 11 Immunoinformatics: The Next Step in Vaccine Design.- 12 Understanding the Shared Bacterial Genome.- 13 Computational Grammars for Annotation and Interrogation of Mobile Genetic Elements.- 14 In silico Discovery of Chemotherapeutic Agents.- 15 Informatics for Healthcare Epidemiology.- 16 Automated, High-throughput Surveillance Systems for Public Health.- 17 Microbial Genotyping Systems for Infection Control.- 18 Temporal and Spatial Clustering of Bacterial Genotypes.- 19 Infectious Disease Ontology.- 20 Populations, patients, germs and genes – ethics of genomics and informatics in communicable disease control.- Glossary.
- ISBN: 978-1-4419-1326-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 434
- Fecha Publicación: 01/12/2009
- Nº Volúmenes: 1
- Idioma: Inglés