Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decision-Making

Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41 covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing INDICE: Part 1 Pharmaceutical product and process synthesis and design 1. Novel product discovery and development for pharmaceutical industry 2. Measurement and property prediction of pharmaceutical compounds Chapter 3: Modeling and prediction of the crystal structure of pharmaceutical molecules 4. Crystal shape engineering for pharmaceutical manufacturing 5. Phase Diagrams based pharmaceutical product formulation 6. Systematic design and synthesis of pharmaceutical manufacturing 7. Plant-wide design and economic evaluation of continuous pharmaceutical production processes Part 2 Pharmaceutical production process modelling, simulation, analysis and optimization 8. Modeling, simulation and analysis of the continuous wet granulation (WG) system 9. Comparative studies on the modelling, simulation and analysis of continuous pharmaceutical manufacturing via roller compaction and direct compaction 10. Plant-wide dynamic model for the continuous pharmaceutical process 11. Reduced-order model development for the complex pharmaceutical manufacturing 12. Data-driven model development for pharmaceutical manufacturing 13. Global sensitivity, feasibility and flexibility analysis of pharmaceutical manufacturing processes 14. Flowsheet optimization for continuous pharmaceutical manufacturing processes Part 3 Pharmaceutical production process dynamics, control, monitoring and operations 15. Process dynamics, and control of API manufacturing and purification processes 16. Model-based control system design and evaluation for continuous tablet manufacturing processes (via direct compaction, via roller compaction, via wet granulation) 17. Advanced hybrid model predictive control of continuous pharmaceutical manufacturing process 18. Advanced control for the continuous dropwise additive manufacturing of pharmaceutical products 19. Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant 20. Intelligent exceptional event management for continuous pharmaceutical tablet manufacturing process 21. Process monitoring and management system for pharmaceutical crystallization processes Part 4 Enterprise-wide optimization for Pharmaceutical Production 22. Enterprise-wide optimization for pharmaceutical manufacturing 23. Pharmaceutical enterprise: R&D Pipeline planning 24. Modeling, algorithms and solution for the production planning of pharmaceutical manufacturing 25. Capacity planning in pharmaceutical manufacturing 26. Supply chain design and management for the pharmaceutical manufacturing 27. Optimal scheduling for the pharmaceutical manufacturing site 28. Optimal production management for the biopharmaceutical manufacturing Part 5 Future directions on the application of process systems engineering to pharmaceutical manufacturing 29. Perspectives for the application of PSE to pharmaceutical manufacturing-views from industry 30. Perspective on PSE in pharmaceutical process development and innovation-views from academia

• ISBN: 978-0-444-63963-9
• Editorial: Elsevier
• Encuadernacion: Cartoné
• Páginas: 612
• Fecha Publicación: 01/03/2018
• Nº Volúmenes: 1
• Idioma: Inglés