The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer andtheir clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mitochondria asbiomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents will also be discussed. Aims to provide a comprehensive analysis of the role mitochondria play in carcinogenesis Will also provide up to date mitochondrial therapeutic approaches for treatment of cancer INDICE: Warburg and the Warburg hypothesis.- The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous.- Oxidative phosphorylation: the link between metabolism and cancer.- Control of glycosis and oxidative phosphorylation in fast growing tumor cells.- The role of citrate metabolism in prostate malignancy and other tumors.- The role of mitochondria in the lipogenic.- Mitochondrial apoptosis pathways in cancer.- Mitochondrial tumor suppressors and neoplastic transformation.- Mitochondrial DNA mutations and tumorigenesis.- SDHD in parganglioma.- Mitochondria in hematogic maliagncies.-Mitochondria and oncocytomas.- Extracellular matrix signaling by mitochondria.- Mitochondria as biomarkers of cancer.- Mitochondria as target of cancer therapy.
- ISBN: 978-0-387-84834-1
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 260
- Fecha Publicación: 01/01/2009
- Nº Volúmenes: 1
- Idioma: Inglés