In Diabetes & C-Peptide: Scientific and Clinical Aspects , a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. AnIntroductory section provides the background and key features of C-peptide’s physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies ofthe type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes. Comprehensive summary of latest evidence on C-peptide and evolving therapies. Written by renowned international experts in the field. Covers both research and clinical issues, including inflammation, cardiovascular complications, neuropathy and nephropathy. INDICE: Preface. Foreword. C-peptide and Insulin – A Happy Marriage. Peptide Interactions of Proinsulin C-peptide. he Effect of Combined C-peptide and Zinc on Cellular Function. C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy. Role of C-Peptide in the Regulation of Microvascular Blood Flow. Is NO-eNOS a target for C-peptide action and its protective effectson diabetic nephropathy?. Renoprotective Effects of C-Peptide in Type I Diabetes. The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy. C-peptide and Type 1 Diabetic Encephalopathy. C-peptide: a New Molecule with Anti-Inflammatory Properties. C-peptide: Connecting Diabetes with Macrovascular Complications. C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes. Proatherogenic Effects of C-Peptide. Conclusions and Future Outlook.
- ISBN: 978-1-61779-390-5
- Editorial: Humana Press
- Encuadernacion: Cartoné
- Páginas: 259
- Fecha Publicación: 28/12/2011
- Nº Volúmenes: 1
- Idioma: Inglés