The goal in focusing on a spectrum of issues related to DC in cancer is to provide an extensive and expansive review rather than a collection of independent analyses from different authors. Specific topics covered include analysis ofDC behavior in the tumor microenvironment, including endogenous and exogenousDC, multiple DC populations, molecular pathways responsible for DC dysfunction, tumor-derived factors altering DC polarization and activation, mechanisms of DC alterations, and the role of DC in tumor escape from immune recognition and elimination. Furthermore, additional chapters provide extensive analysis ofthe consequences of cancer therapy on the DC system and how aging impacts DC function in the tumor microenvironment. Finally, chapters are included examining strengths and pitfalls of current methodologies for generating DC from cancer patients for therapeutic purposes and on the role of tumor-mediated modulation of the DC system in cancer immunotherapy. Presents the very first analysisof published and not-yet published experimental and clinical data related to the immunobiology of DC in tumor-bearing hosts No other publication combines all issues related to immunobiology of DC in cancer in one rationally organizedcomprehensive volume prepared by the leading experts in the field INDICE: From the contents Preface. 1 Introduction: The Dendritic Cell System. 2 Alterations of the Dendritic Cell System in Cancer. 3 Mechanisms of Dendritic Cell Dysfunction in Cancer. 4 Role of the Dendritic Cell System in TumorEscape. 5 Role of tumor-mediated modulation of the DC system in cancer immunotherapy. 6 How to generate DC from cancer patients for therapeutic purposes? 7Future direction in DC research in cancer. Concluding Remarks.
- ISBN: 978-0-387-88610-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 398
- Fecha Publicación: 01/06/2009
- Nº Volúmenes: 1
- Idioma: Inglés