Prognostic Epigenetics, Volume Twelve presents leading chapter authors from across the globe who bring readers from basic science to clinical application. Beginning with a thorough introduction to individual variability in epigenetic processes, lab technology and research methods, the role of DNA methylation, chromatin dynamics, histone modifications, and noncoding RNAs in epigenetic prognostics, the book then explores the epigenetic mechanisms associated with particular disorder prognostics, providing clinicians and researchers with effective tools for the identification and development of biomarkers. Neurological disorders, neurodegenerative disorders, asthma, allergies, metabolic syndromes, obesity, cardiovascular disorders, cancer, infectious disease, autoimmune disorders, and more are covered. Concluding chapters focus on the role of epigenetic biomarkers in personalized medicine, as well as next steps in research and future challenges for the field. Compiles all known information on prognostic epigenetics and its role in preventative medicine and drug discoveryCovers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosisProvides tools for the identification and development of prognostic biomarkers for a wide range of diseasesEnables clinicians, researchers and pharmacologists to improve preventative medicine and precision therapeutics Features chapter contributions from leading international researchers INDICE: 1. It is more than simple genes: The epigenome is more powerful than your genome2. Diagnostic, prognostic and therapeutic potential of the inter-individual variability in the major epigenetic processes: A Clinical Prospective3. Technological advances in studying epigenetics biomarkers for clinical research4. DNA methylation and Chromatin remodeling: Potential prognostic biomarker for disease diagnosis5. Use of post-translational histone modifications for disease diagnosis6. Use of non-coding RNAs as Clinical Biomarkers for disease diagnosis7. The Epigenetic Landscape in Neurological and Neurodegenerative Disorders8. Epigenetic Biomarkers in Asthma and Allergy9. Epigenetics Biomarkers in Metabolic syndrome and Obesity10. Chromatin landscape and Epigenetic biomarkers for clinical diagnosis and prognosis of Type 2 Diabetes mellitus11. Epigenetic biomarkers in Cardiovascular disorders12. Epigenetic biomarkers in Cancer13. Epigenetics in Infectious diseases14. Epigenetics of autoimmune disorders15. Epigenetics of Birth defects16. Epigenetics of adverse pregnancy outcomes17. Epigenetic landscape of Infertility18. Epigenetic landscape of polycystic ovarian syndrome19. Epigenetic biomarkers in ocular disorders20. Epigenetic biomarkers in personalized medicine21. Conclusions and Perspectives. Future Challenges and Prospects for Prognostic Epigenetics and personalized epigenomics
- ISBN: 978-0-12-814259-2
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 504
- Fecha Publicación: 01/08/2019
- Nº Volúmenes: 1
- Idioma: Inglés