Life-span extension: single-cell organisms to man

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man,the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. Multidisciplinary, with viewpoints of experts studying the aging process in species ranging from yeast to man Discusses identificationof common pathways that modulate longevity Provides overview of recent, remarkable discoveries about underlying mechanisms important to aging Explore studies in humans that have identified potentially important markers for successfulaging INDICE: Reprogramming Cell Survival and Longevity: The role of Tor, Sch9, Ras, and Sir2.- Common Aging Mechanisms: Energy Metabolism and Longevity in Caenorhabditis elegans.- Conserved Mechanisms of Life-Span Regulation and Extension in Caenorhabditis elegans.- Drosophila melanogaster.- Overview of the Genetic Architecture of Longevity.- Mild Stress and Life Extension in Drosophila melanogaster.- Rodents.- Global Food Restriction.- Growth Hormone and Aging in Mice.- Comparative Biology of Aging.- Exploiting Natural Variation in Life Span To Evaluate Mechanisms of Aging.- Slow aging: Insights from An ExceptionallyLong-Lived Rodent, the Naked Mole-Rat.- Life Extension in the Short-lived Fish Nothobranchius furzeri.- Aging in Humans.- Aging and Longevity in Animal Models and Humans.- Human aging and longevity within an evolutionary perspective.

• ISBN: 978-1-60327-506-4
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 270
• Fecha Publicación: 01/06/2009
• Nº Volúmenes: 1
• Idioma: Inglés