Self-Organizing Neural Maps: The Retinotectal Map and Mechanisms of Neural Development

Self-Organizing Neural Maps: The Retinotectal Map and Mechanisms of Neural Development: From Retina to Tectum describes the processes underlying how retinal fibers self-organize into an orderly visual map, highlighting almost a century of experiments. The formation of neural maps is a fundamental organizing concept in neurodevelopment and can shed light on developmental mechanisms and the function of genes elsewhere. This book is designed for neuroscientists of all backgrounds, working in all neuroscience subdisciplines, and presents a summary of research in the retinotectal field with the goal of forging a real synthesis on how mechanisms underlying neural development come together harmoniously to bring forth life as we know it. It is appropriate for a broad spectrum of neuroscientists and biomedical scientists with differing backgrounds and varied expertise. Describes the mechanisms of the developmental wiring of the retinotectal systemBrings together the state of the art research in axon guidance and neuronal activity mechanisms in map formationFocuses on topographical maps and inclusion of multiple animal models from fish to mammalsExplores molecular guidance and activity dependent cue components involved in neurodevelopmentAppropriate for neuroscientists in and outside the retinotectal field, with implications for neurobiologyHas great importance for those working with neurodevelopmental diseases, or in neurological and psychiatric translational research INDICE: 1. Overview and Basics of the Retinotectal Projection 2. Early Work Supports, but Also Contradicts, Rigid Chemoaffinity 3. The search for chemoaffinity molecules - verification of molecular gradients 4. Plasticity after surgical ablations shows the limits of chemoaffinity 5. Natural Plasticity - Analysis of the effects of divergent retinal and tectal growth on the projection 6. Specification and developmental genetics of Eph/ephrin gradients 7. Growth of retinal axons along the visual pathway 8. Genetic Analysis of the molecular gradients defining map formation 9. Activity mechanisms shape central retinal projections 10. Activity: Molecular signaling to growth mechanisms

• ISBN: 978-0-12-818579-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/10/2019
• Nº Volúmenes: 1
• Idioma: Inglés