Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. Provides contributions from leading international authorities in the fieldFeatures immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune systemLists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines INDICE: Unraveling the immunologist's dirty little secret?Modulation of innate immunity by particulate adjuvantsDendritic cells as targets and adjuvants in (cancer) vaccinesHost-derived molecules as adjuvantsDiscovery of immune potentiators as vaccine adjuvantsTLR 4 Reed (IDRI)TLR 5TLR 7/8TLR 9 Davis (Pfiser)Inulin adjuvantsNatural adjuvants (e.g. From Propolis)Microparticles as vaccine delivery systemsMF59AS01 adjuvantDevelopment and evaluation of AS04, containing MPL and aluminum saltThe ISCOMATRIXTM adjuvant(CAF)Mineral adjuvantsMucosal vaccines and adjuvantsSkin adjuvantsVaccination to treat non-infectious diseases: Surveying the opportunitiesRegulatory aspects of vaccine adjuvantsConclusion
- ISBN: 978-0-12-804019-5
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 518
- Fecha Publicación: 13/12/2016
- Nº Volúmenes: 1
- Idioma: Inglés