A comprehensive and timely review of developments in the field, Cell and Molecular Biology of Stem Cell Imaging features original and review articles written by experts in their fields. Chapters cover a broad spectrum of the field, from novel imaging with multiphoton flow cytometry for the identification of biomarkers and applications, to embryoid bodies and the central nervous system, and the role of centrosomes in stem cell division and differentiation. The text is a must–read for graduate students and academic and industry professionals in the expanding field of stem cell biology. INDICE: Chapter (Section) 1: Stem Cell Imaging and Novel Imaging Tools Multiphoton flow cytometry to assess intrinsic and extrinsic fluorescence in cellular aggregates: applications to stem cells Dr. Jayne Squirrell and Dr. Brenda Ogle Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI Imaging Hematopoietic Precursor Division in Real Time Dr. Tannishtha Reya Johns Hopkins University School of Medicine, Baltimore, Noninvasive Imaging of Endogenous Neural Stem Cell Mobilization In Vivo Using Positron Emission Tomography Dr. Michael Schroeter Department of Neurology, University Hospital of Cologne, Cologne, Germany An in vivo multimodal imaging study using MRI and PET of stem cell transplantation after myocardial infarction in rats Dr. Kishore K. Bhakoo Stem Cell Imaging, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK Imaging and Analysis of 3D Tumor Spheroids Enriched for a Cancer Stem Cell Phenotype Dr. Sanford H. Barsky University of Nevada School of Medicine, Department of Pathology, Reno, NV, and Nevada Cancer Institute, Las Vegas, NV, USA Molecular imaging of stem cells Dr. Sanjiv Sam Gambhir Molecular Imaging Program at Stanford, Department of Medicine (Cardiology), and Department of Bio–Engineering, Stanford University, Stanford, CA, USA Chapter (Section) 2: Tissue–specific stem cells Overview of hematopoietic stem cells Dr. Andreas Trumpp Deutsches Krebsforschungszentrum (DKFZ), HI–STEM GmbH, Germany Hematopoietic stem cell engraftment of the intestinal tumor microenvironment in ApcMin/+ Mice Dr. Maria Marjorette O. Pena Department of Biological Sciences, University of Carolina, Columbia, SC, and Center for Colon Cancer Research, University of Carolina, Columbia, SC Cardiac and muscle stem cells Dr. Mark A. Krasnow HHMI, Stanford University, USA The hair follicle bulge: a niche for adult stem cells Dr. Hilda Amalia Pasolli Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY Stem cells in adult neurogenesis and hippocampal function Dr. Fred H. Gage The Salk Institute for Biological Studies, Laboratory of Genetics, San Diego, CA Limbal epithelial stem cells of the cornea Dr. Julie T. Daniels Cells for Sight Transplantation and Research Programme, Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK Melanocyte stem cells Dr. Masatake Osawa Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown MA 02129 Pancreatic stem cells Dr. Daniel Kopinke Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA Specification and patterning of the respiratory system Dr. Darrell N. Kotton Pulmonary Center, Boston University School of Medicine, Boston, MA, USA Tooth organogenesis and regeneration Dr. Mark Tummers Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, Helsinki, Finland Uterine stem cells Dr. James K. Pru Vincent Center for Reproductive Biology, Massachusetts General Hospital, Harvard Medical School and Harvard Stem Cell Institute, Boston, MA 02114, USA Chapter (Section) 3: Stem cell biology in animal models Overview of stem cells in non–mammalian models Dr. Phillip Newmark University of Illinois at Champaign–Urbana, USA Annual renewal of adult stem cells in deer antlers Dr. Allan Sheppard AgResearch Ruakura Agricultural Centre, Hamilton, New Zealand Generation of induced pluripotent stem cells in rabbits as potential experimental models for human regenerative medicine Dr. Atsuo Ogura Center for Disease Biology and Integrative Medicine, 5 Faculty of Medicine, University of Tokyo, Bunkyo–ku, Tokyo, Japan Stem cells in animal models of regeneration Dr. Alejandro Sánchez Alvarado Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT Chapter (Section) 4: Genetics and epigenetics of stem cells Stem cell genomic integrity Dr. Maria Blasco Spanish National Cancer Research Centre, Spain Epigenetic programming of stem cells Dr. Yi Zhang University of North Carolina, USA Epigenetic mechanisms controlling mesodermal specification Dr. Maria Jose Barrero The Center of Regenerative Medicine in Barcelona, Barcelona, Spain Genome–wide transcription factor localization and function in stem cells Dr. Bing Lim Genome Institute of Singapore, Singapore and 2Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA Epigenetic silencing during early lineage commitment Dr. Yehudit Bergman Department of Developmental Biology and Cancer Research, Hebrew University Medical School, Ein Kerem, Jerusalem, 91120, Israel Imaging chromatin in embryonic stem cells Dr. Eran Meshorer Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel Stem cells, cancer, and epigenetics Dr. Stephen B. Baylin The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD, USA Chapter (Section) 5: Stem cell biology in reproduction Totipotency and germ line development Dr. Azim Surani Wellcome Trust & Cancer Research UK Gurdon Institute, United Kingdom Pluripotent stem cells and reprogrammed cells in farm animals Dr. Heiner Niemann Institute of Farm Animal Genetics, (FLI), Biotechnology, Mariensee, Neustadt, Germany Stem cell niches and germ line stem cell differentiation: asymmetric centrosome behavior and the mechanisms of stem cell division Dr. Yukiko M. Yamashita Center for Stem Cell Biology, Life Sciences Institute, and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI Mammalian neo–oogenesis in vivo sustained by totipotent ovarian stem cells capable of differentiation into eggs and neuronal cells in vitro Dr. Antonin Bukovsky Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, the University of Tennessee College of Medicine, Knoxville, TN, USA Epithelial stem cells: a folliculocentric view Dr. George Cotsarelis Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA Human ovarian cancer stem cells: Focus on stem cells in human reproduction Dr. Sharmila A Bapat National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune, India Germline stem cell niches Dr. Ting Xie Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA Regulation of spermatogonia Dr. Michael D Griswold School of Molecular Biosciences, Washington State University, Pullman, WA, USA Chapter 6 (Section): Stem cell differentiation Neural stem cells in neurospheres, embryoid bodies and CNS of human embryos Dr. A.Henry Sathananthan Monash Immunology & Stem Cell Laboratories, Monash, Medical, Nursing and Health Sciences, Clayton, Vic, Australia c–Myc promotes differentiation of human epidermal stem cells Dr. Fiona M. Watt Keratinocyte Laboratory, Imperial Cancer Research Fund (ICRF), London, UK Title: Centrosomes and stem cell differentiation – an overview Dr. Allan C. Spradling Department of Embryology and Howard Hughes Medical Institute, Carnegie Institution,Baltimore, MD 21218, USA. Chapter (Section) 7: Aging and stem cells Stem cell metabolism and aging Dr. Margaret A. Goodell Baylor College of Medicine, USA Lamin A–dependent misregulation of adult stem cells associated with accelerated ageing Dr. Paola Scaffidi National Cancer Institute, NIH, Bethesda, Maryland, 20892 Aging and stem cell renewal Dr. Irina M. Conboy Department of Bioengineering, University of California, Berkeley, Berkeley, California, USA Chapter (Section) 8: Stem cell immunology Immunologic targeting of the cancer stem cell Dr. Catherine J. Wu Cancer Vaccine Center and Department of Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA Immunological considerations for cell therapy using human embryonic stem cell derivatives Dr. Micha Drukker Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA Chapter (Section) 9: Stem cell biology and regenerative medicine Overview of stem cell biology and regenerative medicine Dr. Janet Rossant Hospital for Sick Children, Canada Engineering microenvironments to control stem cell fate and function Dr. David V. Schaffer Chemical Engineering, Bioengineering, and the Helen Wills Neuroscience Institute University of California, Berkeley, California 94720, USA Medical applications of epidermal stem cells Dr. Cédric Blanpain IRIBHM, Université Libre de Bruxelles, Brussels, Belgium Chapter (Section) 10: Stem cell therapies Overview of therapeutic approaches to stem cells Dr. Kenneth R. Chien Massachusetts General Hospital, USA Small molecule approach to stem cells Dr. Tewis Bouwmeester NIBR – Novartis Pharma AG, Switzerland Cell therapy Dr. Christine L. Mummery Leiden University Medical Center, Netherlands Peripheral blood stem cells for allogeneic transplantation: a review Dr. Joseph H. Antin Department of Adult Oncology, Dana–Farber Cancer Institute and Department of Medicine, Brigham and Women?s Hospital, Boston, Massachusetts, USA Cord blood hematopoietic stem cell transplantation Dr. Hal E. Broxmeyer Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA Chapter (Section) 11: Skin cells as stem cell resources Overview of epithelial stem cells and skin cells as stem cell resources Dr. Valerie Horsley Yale Stem Cell Center, US Chapter (Section) 12: Practical tissue engineering Stem cells and tissue engineering Dr. Laura E. Niklason Yale University, USA Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery Dr. Shelly E. Sakiyama–Elbert Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA Bone tissue engineering Dr. Antonios G. Mikos Department of Bioengineering, Rice University, Houston, Texas, USA Skin tissue engineering Dr. Howard Y. Chang Program in Epithelial Biology, Stanford University, Stanford, CA Chapter (Section) 13: Embryonic stem cells Overview of human embryonic stem cells Dr. Duanqing Pei Guangzhou Institutes of Biomedicine and Health CAS, China Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells Dr. Kevin Eggan Howard Hughes Medical Institute, Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA Derivation, growth and applications of human embryonic stem cells Dr. Miodrag Stojkovic Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK Fates of donor and recipient mitochondrial DNA during generation of interspecies SCNT–derived human ES–like cells Dr. Jian–hong Zhu Department of Neurosurgery, Fudan University Huashan Hospital, National Key Laboratory for Medical Neurobiology, Fudan University, Shanghai, China, 200040 Chapter (Section) 14: Stem cell signaling Reprogramming and stem cell fate conversion Dr. Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA Regulatory networks of stem cells Dr. Richard A. Young Whitehead Institute for Biomedical Research, USA The role of centrosomes in stem cell signaling and fate determination Dr. Heide Schatten University of Missouri, Columbia, MO Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells Dr. Arturo Alvarez–Buylla Department of Neurological Surgery, Institute for Regeneration Medicine, University of California San Francisco, San Francisco, California 94143, USA Targeting Hedgehog – a cancer stem cell pathway Dr. William Matsui Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD Chapter (Section) 15: Stem cells and cancer – drug development Overview of stem cells and cancer Dr. Jane E. Visvader Institute of Medical Research, Australia Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models Dr. John Condeelis Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY Chapter (Section) 16: Stem Cell websites and resources
- ISBN: 978-1-118-28410-0
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 312
- Fecha Publicación: 22/10/2014
- Nº Volúmenes: 1
- Idioma: Inglés